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Diss Factsheets

Administrative data

Endpoint:
genetic toxicity in vitro
Type of information:
calculation (if not (Q)SAR)
Remarks:
Migrated phrase: estimated by calculation
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Values are predicted from model. Thus, they provide an approximation compared to experimental measure.

Data source

Reference
Reference Type:
other: unpublished calculation
Title:
Unnamed
Year:
2013

Materials and methods

Principles of method if other than guideline:
The following models were applied to examine for structural alerts that indicate the mutagenic potential of yttrium chromite using ChemProp:
Mutagenicity by Kazius et al.
Mutagenicity by Benigni et al.
Micronucleus assay by Benigni et al.
Type of assay:
other: estimated by calculation

Test material

Constituent 1
Chemical structure
Reference substance name:
chromium yttrium oxide (1:1:3)
Cas Number:
12182-76-2
Molecular formula:
YCrO3
IUPAC Name:
chromium yttrium oxide (1:1:3)
Test material form:
not specified
Details on test material:
Calculation is based on the structure of yttrium chromite.

Results and discussion

Test results
Species / strain:
not specified
Metabolic activation:
not specified
Genotoxicity:
not specified
Cytotoxicity / choice of top concentrations:
not specified
Additional information on results:
Mutagenicity by Kazius et al. (1=active; 0= inactive): 0 - mismatch of chemical domains
Mutagenicity by Benigni et al. (1=active; 0= inactive): 0
Micronucleus assay by Benigni et al. (1=active; 0= inactive): 0

Applicant's summary and conclusion

Conclusions:
There are no structural alerts that yttrium chromite might has mutagenic potential.
Executive summary:

We tested for structural alerts that indicate mutagenic potential of yttrium chromite, using ChemProp. For Mutagenicity the models by Kazius et al. and by Benigni et al. were used and additionally we applied the model: Micronucleus assay by Benigni et al. All models indicate that there are no structural alerts that yttrium chromite might has mutagenic potential.