Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 224-815-8 | CAS number: 4501-58-0
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not stated
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP study with no information on methods to determine acceptability of study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
- Principles of method if other than guideline:
- No information available.
- GLP compliance:
- not specified
- Limit test:
- yes
Test material
- Reference substance name:
- (R)-2,2,3-trimethylcyclopent-3-ene-1-acetaldehyde
- EC Number:
- 224-815-8
- EC Name:
- (R)-2,2,3-trimethylcyclopent-3-ene-1-acetaldehyde
- Cas Number:
- 4501-58-0
- Molecular formula:
- C10H16O
- IUPAC Name:
- (R)-2,2,3-trimethylcyclopent-3-ene-1-acetaldehyde
- Details on test material:
- - Name of test material: Aldehyde Campholenique
Constituent 1
Test animals
- Species:
- rabbit
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Doses:
- 5 g/kg
- No. of animals per sex per dose:
- 10
- Control animals:
- no
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- None
- Clinical signs:
- other: Prostration, yellow exudate at nose, ataxia, ptosis, respiratory distress, lethargy, diarrhea, abdomen bloated, emaciated, mucous in stool, alopecia
- Other findings:
- SKIN IRRITATION
Redness day 1 - none 3/10; severe 7/10
Oedema, moderate - 10/10
Any other information on results incl. tables
Table 1: Necropsy observations
| 5.00 g/kg | |
| Exudate, nose/mouth, yellow | 1 |
| Anogenitial, areas yellow | 4 |
| Intestines, bloated | 4 |
| Lungs, areas dark | 2 |
| Kidney, mottled | 1 |
| Lungs, bright orange | 3 |
| Skin, edema | 6 |
| Skin, redness | 6 |
| Skin hard/thick | 2 |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of the test, the acute dermal toxicity of the test substance was determined to be LD50 >5000 mg/kg.
- Executive summary:
In a non-GLP acute dermal toxicity study, the acute dermal toxicity of the test substance was determined to be LD50 >5000 mg/kg.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
