Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
additional ecotoxicological information
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Non-guideline, non-GLP study from the published, peer-reviewed literature in which the investigations described do not totally comply with with a specific testing guideline, but which are well-documented and scientifically acceptable.

Data source

Reference
Reference Type:
review article or handbook
Title:
An Updated Review of Environmental Estrogen and Androgen Mimics and Antagonists
Author:
Sonnenschein, C and Soto AM
Year:
1998
Bibliographic source:
Journal of Steroid Biochemistry And Molecular Biology 65(1-6):143-150 1998.

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Review article
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Dimethyl isophthalate
EC Number:
215-951-9
EC Name:
Dimethyl isophthalate
Cas Number:
1459-93-4
Molecular formula:
C10H10O4
IUPAC Name:
1,3-dimethyl benzene-1,3-dicarboxylate

Results and discussion

Any other information on results incl. tables

Both dimethyl isophalate and its isomer dimethyl terephthalate were found to be non-estrogenic xenobiotics when tested by the E-SCREEN assay.

Applicant's summary and conclusion

Conclusions:
Dimethyl isophalate and its isomer dimethyl terephthalate were found to be non-estrogenic xenobiotics when tested by the E-SCREEN assay.