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EC number: 203-341-5 | CAS number: 105-87-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The hydrolysis and degradation of Geranylacetat Extra in plasma, liver and gastrointestinal tract was investigated. To determine hydrolysis in either compartment, the test substance was incubated with plasma and liver-S9 fraction from rat as well as in gastric-juice simulant and intestinal-fluid simulant. After incubation, the proteins were precipitated and the amount of remaining substrate was analysed in the supernatant by GC/FID.
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Experimental Toxicology and Ecology
Test material
- Reference substance name:
- Geranyl acetate
- EC Number:
- 203-341-5
- EC Name:
- Geranyl acetate
- Cas Number:
- 105-87-3
- Molecular formula:
- C12H20O2
- IUPAC Name:
- 3,7-dimethylocta-2,6-dien-1-yl acetate
- Test material form:
- other: liquid
- Details on test material:
- Test Substance:
- Name of test material (as cited in study report): Geranylacetat Extra
- Physical state: liquid / yellowish, clear
- Analytical purity: 98.9 corr. area-%
- Test substance No.: 09/0294-3
- Batch No.: Ch 00006277L0
- Expiration date of the lot/batch: 04 Feb 2015
- Storage condition of test material: refrigerator(KS); under light exclusion ; air sensitive
- Homogeneity: given (vis)
Reference Substance 1:
- Name of reference material (as cited in study report): Geraniol Extra
- Physical state: liquid / yellowish, clear
- CAS No.: 106-24-1
- Analytical purity: 98.4 corr. area-%
- Test substance No.: 10/0046-2
- Batch No.: 00028577L0
- Expiration date of the lot/batch: 14 Aug 2013
- Storage condition of test material: ambient (RT); under light exclusion
- Homogeneity: given (vis)
Reference Substance 2:
- Name of reference material (as cited in study report): Benzyl benzoate
- Physical state: liquid / colorless, clear
- CAS No.: 120-51-4
- Analytical purity: 99.9%
- Test substance No.: 12/0416-1
- Batch No.: MKBG9990V
- Expiration date of the lot/batch: Apr 2016
- Storage condition of test material: ambient
- Homogeneity: given (vis)
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- other: not applicable (in vitro test)
- Details on test animals or test system and environmental conditions:
- not applicable (in vitro test)
Administration / exposure
- Route of administration:
- other: not applicable (in vitro test)
- Duration and frequency of treatment / exposure:
- see "Any other information on materials an methods incl. tables"
Doses / concentrations
- Remarks:
- Doses / Concentrations:
see "Any other information on materials an methods incl. tables"
- No. of animals per sex per dose / concentration:
- not applicable (in vitro test)
- Control animals:
- other: not applicable (in vitro test)
- Positive control reference chemical:
- see "Any other information on materials an methods incl. tables"
- Statistics:
- For calculation of the hydrolysis (turn over), peak areas of the substrates of active incubation (AI) and heat deactivated control (HDC) were used. Buffer controls were used to calculate the substrate recovery of the HDC and t=0 control.
Calculation of the turn over in plasma, liver- S9 fraction and intestine-fluid simulant:
% turn-over = 100 * (peak area (HDC) – peak area (AI)) / peak area (HDC)
Calculation of the turn-over in gastric-juice simulant:
% turn-over = 100 * (peak area (t=0) – peak area (AI)) / peak area (t=0)
Results and discussion
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- Geranylacetat Extra hydrolyzed within 0.5h completely in rat plasma (100%), liver S9 fraction of rats (100%) and intestinal-fluid simulant (100%) under the test conditions used. For gastric juice simulant the metabolic turn over that is related to t=0 control was calculated to be 25, 46 and 59% after an incubation period of 0.5, 1 and 2 h, respectively.
Applicant's summary and conclusion
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