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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Reference
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
For the detailed read across justification please refer to the attached pdf file.
Reason / purpose for cross-reference:
read-across source
Key result
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
> 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Duration:
48 h
Dose descriptor:
NOEC
Effect conc.:
>= 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility

Description of key information

With high probability acutely not harmful to aquatic invertebrates. 

Key value for chemical safety assessment

Additional information

According to regulation (EC) No 1907/2006, Annex XI, paragraph 1.5., substances whose physicochemical, toxicological and ecotoxicological properties are likely to be similar or follow a regular pattern as a result of structural similarity may be considered as a group, or "category" of substances. Environmental effects or environmental fate may be predicted from data for reference substance(s) within the group by interpolation to other substances in the group (read-across approach).

The toxicity of Daphnia magna of a structural analogue was studied in a 48 h static test according to OECD 202. A supersaturated dispersion of the test item with a loading rate of 100 mg/L continuously stirred at room temperature in the dark over 96 h and a control was used in the test. No immobilized test organisms were determined during the test period of 48 hours. Thus, the 48 -h EC50 were determined to be at the loading rate of 100 mg/L.

In a disregarded study the 24–hr-acute toxicity of the test item to Daphnia magna was determined under static conditions. Daphnids were exposed to control and test item at nominal concentration of 1.8, 3.2, 5.8, 10, 18, 32, 58 and 100 mg/L for 24 hr. Mortality/immobilization and sublethal effects were observed daily. The 24–hr EC50 was 15 mg/L. The 24–hr EC0 based on immobilization was > 100 mg/L.

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