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Diss Factsheets

Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

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Administrative data

Link to relevant study record(s)

Description of key information

No toxic effects to aquatic algae up to the limit of water solubility (< 0.05 mg/L).

Key value for chemical safety assessment

Additional information

In accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 a read across to a structurally related category membersfatty acids, C16-18, esters with pentaerythritol(CAS 85116-93-4) was conductedto fulfill the data requirements according to Annex VII-IX of fatty acids, C16-18 and C18-unsaturated, esters with pentaerythritol (CAS 85711-45-1) in regard to toxicity to aquatic algae and cyanobacteria. This read-across is justified in detail in the overall summary (IUCLID chapter 6.1) and within the category justification in IUCLID Section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substances were used for the assessment. The fatty acid chain lengths of C16 and C18 of the read-across substance are identical to those of the target substance. In addition, the read-across as well as the target substance contain the same alcohol component, i.e. pentaerythritol, and are mono to tetra-ester.

The study with the read-across substancefatty acids, C16-18, esters with pentaerythritol(CAS 85116-93-4) was performed according to EPA OPPTS 850.5400 (Algal Toxicity, Tiers I and II) under GLP conditions (Scheerbaum, 2007). The green algae Pseudokirchneriella subcapitata was exposed to nominal concentrations of 10 mg/L, 30 mg/L and 100 mg/L. The test solution was prepared by adding the appropriate amount of test substance with subsequent stirring and sampling of the aqueous portions (WAFs). An EL50 (72 h) > 100 mg/L (nominal) was determined based on effects on growth rate and on biomass.

Based on this result from a structurally related read-across substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which is characterized by a similar ecotoxicological profile, it can be concluded thatfatty acids, C16-18 and C18-unsaturated, esters with pentaerythritol (CAS 85711-45-1)will not exhibit effects to aquatic algae up to the limit of water solubility.As it can be seen in the data matrix of the category justification in section 13 and the overall endpoint summary IUCLID 6.1, all reliable data in the polyol esters category support this hazard assessment by showing a consistent pattern of results, i.eno toxic effects were observed to aquatic organisms up to the limit of water solubility.