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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Meets generally accepted scientific standards, well documented and acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Studies on the design of animal tests for the corrosiveness of industrial chemicals
Author:
Potokar M, Grundler OJ, Heusener A, Jung R, Mürmann P, Schöbel C, Suberg H, Zechel HJ
Year:
1985
Bibliographic source:
Fd. Chem. Toxic. 23(6): 615-617

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Titanium tetrachloride
EC Number:
231-441-9
EC Name:
Titanium tetrachloride
Cas Number:
7550-45-0
Molecular formula:
Cl4Ti
IUPAC Name:
titanium tetrachloride

Test animals

Species:
rabbit
Strain:
New Zealand White
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: various breeders, not specified
- Weight at study initiation: 2-4 kg
- Housing: individually
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: no data


ENVIRONMENTAL CONDITIONS
standardized laboratory conditions, no further data

Test system

Type of coverage:
semiocclusive
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Controls:
other: untreated skin of the same animals
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 in ml or g
Duration of treatment / exposure:
1 and 4 hours
Observation period:
7 days
Number of animals:
6 for each exposure time
Details on study design:
TEST SITE
- Area of exposure: dorsal and lateral parts of the trunk
- % coverage: unspecified, gauze pads with 3x3 cm were used
- Type of wrap if used: air permeable circular bandage


REMOVAL OF TEST SUBSTANCE
- Washing (if done): rinsed with water and dried
- Time after start of exposure: either after 1 or 4 hours


SCORING SYSTEM: as described in the OECD guideline 404

Results and discussion

In vivo

Results
Irritation parameter:
other: full thickness destruction
Basis:
mean
Time point:
other: 1 h
Score:
> 4
Max. score:
4
Reversibility:
not reversible

Any other information on results incl. tables

The publication indicates that semi-occlusive exposure of the shaved rabbit skin to titanium tetrachlorid for 1 and 4 hours leads to a labbeling with R34 as titanium tetrachlorid is corrosive according to EU-criteria. This means that full thickness destruction of the skin occured after exposure for 1 hour. The test substance therefore has to be classified in Cat. 1B (skin irritation/corrosion) according to GHS-criteria.

Applicant's summary and conclusion

Interpretation of results:
corrosive
Remarks:
Migrated information