Registration Dossier
Registration Dossier
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EC number: 601-770-6 | CAS number: 121315-20-6
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- GLP compliance:
- yes (incl. QA statement)
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Details on test material:
- FAT 92274/B
Constituent 1
Results and discussion
Any other information on results incl. tables
In experiment I, toxic effects, evidenced by a reduction in the number of revenants, occurred without metabolic activation in strain TA 98 from 1000.0 ug/plate up to 5000.0 ug/plate. In experiment II, toxic effects occurred at 5000.0 ug/plate without metabolic activation in strain TA 100, and with and without metabolic activation in strains TA 1535, TA 1537, and TA 98. The plates incubated with the test article showed normal background growth up to 5000.0 ug/plate with and without S9 mix in all strains used. No substantial increases in revertant colony numbers of any of the four tester strains were observed following treatment with 2(3-Amino-benzamino)ethylsulfonylethylhydrogensulfat feucht at any concentration level, either in the presence or absence of metabolic activation (S9 mix). There was also no tendency of higher mutation rates with increasing concentrations in the range below the generally acknowledged border of biological relevance. Appropriate reference mutagens were used as positive controls. They showed a distinct increase in induced revertant colonies.
Applicant's summary and conclusion
- Conclusions:
- In conclusion, it can be stated that during the described mutagenicity test and under the
experimental conditions reported, the test article did not induce gene mutations by base pair
changes or frameshifts in the genome of the strains used. - Executive summary:
did not induce gene mutations
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