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EC number: 700-672-1 | CAS number: 70226-26-5
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
Reaction products of lauric acid and oxybis(propanediol) exhibits a low potential for bioaccumulation.
Key value for chemical safety assessment
Additional information
No experimental data evaluating the bioaccumulation potential of Reaction products of lauric acid and oxybis(propanediol) (List No. 700-627-1) are available. Therefore, QSAR calculations have been performed on the most representative components (diglycerol monolaurate and diglycerol dilaurate) of the (UVCB) substance using the BCFBAF v3.01 program. The results obtained with the regression-based method show BCF values ranging from 30.2 – 515 L/kg wet weight (for diglycerol monolaurate and diglycerol dilaurate respectively, Hopp, 2011). Nevertheless,when including biotransformation rate constants, both, the BCF and BAF, showed significantly lower values, 1.20 and 4.07 L/kg, respectively (Arnot-Gobas estimate, including biotransformation, upper trophic; Hopp, 2011).Based on these results, biotransformation can be expected to be an important process to be considered when evaluating the bioaccumulation potential of this substance in aquatic organisms. Reaction products of lauric acid and oxybis(propanediol) is basically formed by different C12 fatty acid esters. Ester compounds are known to be metabolized by carboxylesterases (a group of ubiquitous and low substrate specific enzymes) into fatty acids and the corresponding alcohols in both vertebrates and invertebrate species, including fish (Leinweber, 1987). Fatty acids are naturally occurring components, known to participate in standard physiological processes in living organisms (lipid synthesis, citric acid cycle, etc)(Frayn et al., 2006)(Schnurr et al., 2002). In fish species, a fraction of the free fatty acids is expected to be re-esterified with glycerol and partial acyl glycerols to form triglycerides that will be stored as long-term energy reserves. Especially in periods in which the energy demand is high (reproduction, migration, etc.), these glycerides will be mobilized from the storage sites as source of fatty acids. Fatty acid catabolism is the most important energy source in many species of fish, resulting in the release of acetyl CoA and NADH (through β-oxidation) and eventually, via the tricarboxylic cycle, the production of metabolic energy in the form of ATP. This fatty acid-catabolism pathway is the predominant source of energy related to growth, reproduction and development from egg to adult fish (Tocher, 2003).
Reaction products of lauric acid and oxybis(propanediol) is a readily biodegradable substance. According to the Guidance on information requirements and chemical safety assessment, Chapter R.7b, readily biodegradable substances can be expected to undergo rapid and ultimate degradation in most environments, including biological Sewage Treatment Plants (STPs)(ECHA, 2008). Therefore, only low concentrations of these substances are likely to be (if at all) released into the environment and available to (aquatic) organisms.
The collected information on expected bioavailability and fatty acid esters metabolism in combination with the estimated BCF/BAF values obtained for Reaction products of lauric acid and oxybis(propanediol) (List No. 700-627-1) strongly indicates that this substance will show low bioaccumulation potential in biota.This conclusion is in line with the recent assessment of substances as defined by the US-EPA HPV Aliphatic Diester Category (US-EPA, 2010).
References
European Chemicals Agency (ECHA, 2008). Guidance on information requirements and chemical safety assessment, Chapter R.7b: Endpoint specific guidance
Frayn, K.N., Arner, P. and Yki-Järvinen, H. (2006). Fatty acid metabolism in adipose tissue, muscle and liver in health and disease. Essays of Biochemistry, 42: 89–103
Heath, R.J., Jackowski, S., and Rock, C.O. (2002). Fatty acid and phospholipid metabolism in prokaryotes. Biochemistry of Lipids, Lipoproteins and Membranes (Vance and Vance, eds. 4th Edition)
Leinweber, F.J. (1987). Possible physiological roles of carboxylic ester hydrolases. Drug Metabolism Reviews, 18: 379-439
Schnurr, J.A., Shockey, J.M., de Boer, G.J. and Browse, J.A. (2002). Fatty Acid Export from the Chloroplast. Molecular Characterization of a Major Plastidial Acyl-Coenzyme A Synthetase from Arabidopsis. Plant Physiology, 129: 1700-1709
Tocher, D.R. (2003). Metabolism and Functions of Lipids and Fatty Acids in Teleost Fish. Reviews in Fisheries Science, 11(2): 107-184
US-EPA. 2010. Diesters Category of the Aliphatic Esters Chemicals (Test Plan and Robust Summaries for Substances in the HPV Test Plan). High Production Volume (HPV) Chemical Challenge Program (201-16837A and 201-16837B). accessed: http://www.epa.gov/hpv/pubs/summaries/alipestr/c13466tc.htm (04 Nov 2011)
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