Registration Dossier

Administrative data

Endpoint:
in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
Remarks:
Type of genotoxicity: chromosome aberration
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study submitted in the ELINCS notification dossier.

Data source

Reference
Reference Type:
study report
Title:
Unnamed

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
GLP compliance:
yes
Type of assay:
micronucleus assay

Test material

Constituent 1
Chemical structure
Reference substance name:
2-(phenylmethoxy)naphthalene
EC Number:
405-490-3
EC Name:
2-(phenylmethoxy)naphthalene
Cas Number:
613-62-7
Molecular formula:
C17H14O
IUPAC Name:
2-(benzyloxy)naphthalene

Test animals

Species:
mouse
Strain:
NMRI
Sex:
male/female

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
maize oil
Duration of treatment / exposure:
24 or 48 hours after treatment
Post exposure period:
24 or 48 hr for the highest dose. Only 24 h for the others.
Doses / concentrationsopen allclose all
Remarks:
Doses / Concentrations:
200 mg/kg
Basis:
no data
Remarks:
Doses / Concentrations:
670 mg/kg
Basis:
no data
Remarks:
Doses / Concentrations:
2000 mg/kg
Basis:
no data
No. of animals per sex per dose:
5

Results and discussion

Test results
Sex:
male/female
Genotoxicity:
negative
Toxicity:
yes
Remarks:
at 2000 mg/kg (reduced spontaneous activity, reversible within 24 h
Vehicle controls validity:
not specified
Negative controls validity:
not specified
Positive controls validity:
not specified
Additional information on results:
24h :
200 mg/kg PCE/NCE: 1000/644
670 mg/kg PCE/NCE: 1000/687
2000 mg/kg PCE/NCE: 1000/663

48 h:
2000 mg/kg PCE/NCE: 1000/643

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): negative
The substance doesn't induce micronucleus in the mouse
Executive summary:

The micronucleus test has been performed in mouse (males and females) with the substance by ip injection of 200 to 2000 mg/kg. The micronucleus were determined at 24 or 48 h after treament for the highest tested dose and at 24 h only for 200 and 670 mg/kg. Sign of toxicity were observed at 2000 mg/kg.

In the conditions of this test, the substance didn't induce positive results.