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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Report date:
1997

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Qualifier:
according to guideline
Guideline:
EU Method B.1 (Acute Toxicity (Oral))
GLP compliance:
yes (incl. QA statement)
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
4-(trifluoromethyl)benzoyl fluoride
EC Number:
206-715-6
EC Name:
4-(trifluoromethyl)benzoyl fluoride
Cas Number:
368-94-5
Molecular formula:
C8H4F4O
IUPAC Name:
4-(trifluoromethyl)benzoyl fluoride

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
corn oil
Doses:
First dose 2000 mg/kg
A second dose of 200 mg/kg to an additional group of 5 male and 5 female
A third dose fo 1000 mg/kg to an additional group of 5 male and 5 female
No. of animals per sex per dose:
5

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
1 178 mg/kg bw
Based on:
test mat.
Mortality:
200 mg/kg dose : 0% of mortality in males and females
1000 mg/kg dose : 0% of mortality in males; 20% of mortality in females
2000 mg/kg dose : 100% of mortality in males and females
Clinical signs:
Sedation, convulsions, hunched posture, ventral recumbency, uncoordinated movements, dyspnea, diarrhea and /or ruffled fur were obseved in the animals of dose group 2000 mg/kg.
Sedation, hunched posture, dyspnea, emaciation, lids half closed and/or ruffled fur were observed in the animals of dose group 100 mg/kg. No clinical signs were observed in the animals of dose group 200 mg/kg.
Body weight:
within the range
Gross pathology:
white discolored lungs was observed in one female of dose group 2000 ng/kg. No macroscopic findings in the other animals.

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The median lethal dose for the acute oral toxicity in rats of both sexes observed for a period of 14 days is: LD50 1178 mg/kg.

for males 1174 mg/kg
for females 1031 mg/kg

with 90% CI of:
males/females 771-2324 mg/kg
males 601-5085 mg/kg
females 561-2843 mg/kg

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