3,4-dichloro-α,α,α-trifluorotoluene

Toxicity to reproduction

Administrative data

Endpoint:

one-generation reproductive toxicity

Remarks:

based on test type (migrated information)

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Available data in the IUCLID Chemical Data Sheet; the data have not undergone any evaluation by the European Commission. The method is not known.

Data source

Reference

Reference Type:

grey literature

Title:

Unnamed

Year:

2000

Report date:

2000

Materials and methods

Principles of method if other than guideline:

Method not known

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

3,4-dichloro-α,α,α-trifluorotoluene

EC Number:

206-337-1

EC Name:

3,4-dichloro-α,α,α-trifluorotoluene

Cas Number:

328-84-7

Molecular formula:

C7H3Cl2F3

IUPAC Name:

1,2-dichloro-4-(trifluoromethyl)benzene

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Administration / exposure

Route of administration:

oral: gavage

Duration of treatment / exposure:

Exposure period: 14 days

Frequency of treatment:

daily

Doses / concentrations

Remarks:

Doses / Concentrations:
5, 15, 45 mg/kg/day
Basis:

Control animals:

yes

Results and discussion

Results: F1 generation

Effect levels (F1)

Dose descriptor:

NOAEL

Generation:

F1

Effect level:

15 - 45 mg/kg bw/day

Based on:

not specified

Sex:

not specified

Overall reproductive toxicity

Reproductive effects observed:

not specified