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Environmental fate & pathways

Hydrolysis

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Description of key information

According to the EEC Directive 92/69, Section G.7, the method is applicable only to water soluble substances. The test item is insoluble in water. The test item was also found to be insoluble in buffer solutions with 1 % NMP as solubilizer. Therefore, no further testing could be performed with test item at pH 4.0, pH 7.0 and pH 9.0.

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Additional information

The hydrolysis determination of the test item at different pH values was based on the OECD Guideline No. 111 , "Hydrolysis as a Function of pH"; adopted May 12, 1981 and on the EEC Directive 92/69, Section C.7, "Abiotic Degradation: Hydrolysis as a Function of pH", L383 A, December 1992 (RCC Ltd. 2004a). The solubility of test item in the buffer solutions pH 4.0, pH 7.0 and pH 9.0 was very low. It was not possible to increase the solubility of the test item with the use of NMP (most appropriate according to a solubility test) as solubilizer. Peaks obtained, if any, were too small to allow quantification or even to follow a degradation curve. The calibration data for test item-standards showed a r fit of 1.0000 (optimum 1.0000) reflecting the linearity of the HPLC-system within the calibration range of 0.932 µg/mL to 55.92 µg/mL of the test item. According to the EEC Directive 92/69, Section G.7, the method is applicable only to water soluble substances. The test item is insoluble in water. The test item was also found to be insoluble in buffer solutions with 1 % NMP as solubilizer. Therefore, no further testing could be performed with test item at pH 4.0, pH 7.0 and pH 9.0.