Registration Dossier
Registration Dossier
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EC number: 444-370-5 | CAS number: 669005-94-1
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
The 3-hour NOEC (EC15) of the test item to activated sludge microorganisms was at least 100 mg/L. Concentrations above 100 mg/L were not tested. No acute toxic effects occurred within the range of water solubility.
Key value for chemical safety assessment
Additional information
The inhibitory effect of the test item on the respiration rate of aerobic wastewater microorganisms of activated sludge was investigated in a 3-hour respiration inhibition test according to the EU Commission Directive 88/302/EEC, Part C.11, and the OECD Guideline for Testing of Chemicals, No. 209 (RCC Ltd. 2004d). The following nominal concentrations of test item were tested: 6.3, 12.5, 25, 50, and 100 mg/L. Concentrations above 100 mg/L were not tested. In addition, two controls and three different concentrations of the reference item 3,5-dichlorophenol (5, 16, and 50 mg/L) were tested in parallel. The results of these treatments confirmed the suitability of the activated sludge and the method used. Up to and including the nominalconcentration of 100 mg/L, the test item had no inhibitory effect on the respiration rate of activated sludge after the incubation period of three hours. Down to the lowest test concentration of 6.3 mg/L, the test item was not completely dissolved in the test media. The saturation concentration was obviously reached and resulted in less than 15% inhibition of the respiration rate. Thus, the 3-hour NOEC (EC15) of the test item to activated sludge microorganisms was at least 100 mg/L. The 3-hour EC20, EC50, and EC80 could not be calculated but were clearly higher than 100 mg/L or above the solubility limit of the test item in test water.
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