Registration Dossier
Registration Dossier
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EC number: 403-800-1 | CAS number: 103597-45-1 EVERSORB 78; LOWILITE 36; LS.BT.620; MIXXIM BB/100; TINUVIN 360
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP compliance and OECD method
Data source
Reference
- Reference Type:
- other: ECHA inquiry result
- Title:
- Unnamed
- Year:
- 2 013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD402
- GLP compliance:
- yes
- Limit test:
- yes
Test material
- Reference substance name:
- 2,2'-methylenebis(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol)
- EC Number:
- 403-800-1
- EC Name:
- 2,2'-methylenebis(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol)
- Cas Number:
- 103597-45-1
- Molecular formula:
- C41H50N6O2
- IUPAC Name:
- 2-(2H-1,2,3-benzotriazol-2-yl)-6-{[3-(2H-1,2,3-benzotriazol-2-yl)-2-hydroxy-5-(2,4,4-trimethylpentan-2-yl)phenyl]methyl}-4-(2,4,4-trimethylpentan-2-yl)phenol
Constituent 1
Test animals
- Species:
- other: rat, Tif;RAIF(SPF)
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- other: 0.5(w/v)carboxymethylcellulose in 0.1%(w/v) acqueous polysorbate
- Duration of exposure:
- 24 h
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- Male:2000 mg/kg bw;Number of animals:5; Number of deaths:0
Female:2000 mg/kg bw;Number of animals:5; Number of deaths:0 - Clinical signs:
- other: Signs of toxicity related to dose levels; Piloerection and hunched posture were observed during the study, as is normal with acute studies. All animals revovered within three days.
- Gross pathology:
- Effects on organs:
No deviation from normal morphology was observed at autopsy
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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