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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP compliance and OECD method

Data source

Reference
Reference Type:
other: ECHA inquiry result
Title:
Unnamed
Year:
2013

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: OECD402
GLP compliance:
yes
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
2,2'-methylenebis(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol)
EC Number:
403-800-1
EC Name:
2,2'-methylenebis(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol)
Cas Number:
103597-45-1
Molecular formula:
C41H50N6O2
IUPAC Name:
2-(2H-1,2,3-benzotriazol-2-yl)-6-{[3-(2H-1,2,3-benzotriazol-2-yl)-2-hydroxy-5-(2,4,4-trimethylpentan-2-yl)phenyl]methyl}-4-(2,4,4-trimethylpentan-2-yl)phenol

Test animals

Species:
other: rat, Tif;RAIF(SPF)

Administration / exposure

Type of coverage:
semiocclusive
Vehicle:
other: 0.5(w/v)carboxymethylcellulose in 0.1%(w/v) acqueous polysorbate
Duration of exposure:
24 h

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
Male:2000 mg/kg bw;Number of animals:5; Number of deaths:0
Female:2000 mg/kg bw;Number of animals:5; Number of deaths:0
Clinical signs:
other: Signs of toxicity related to dose levels; Piloerection and hunched posture were observed during the study, as is normal with acute studies. All animals revovered within three days.
Gross pathology:
Effects on organs:
No deviation from normal morphology was observed at autopsy

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU