Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: study equivalent to EU/OECD guideline.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1981

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
no
Test type:
acute toxic class method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-chlorobenzamide
EC Number:
210-195-6
EC Name:
2-chlorobenzamide
Cas Number:
609-66-5
Molecular formula:
C7H6ClNO
IUPAC Name:
2-chlorobenzamide

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: acetone/oil 2/10
Doses:
50, 500, 1000, 1250, 1500, 1750, 2000 mg/kg
No. of animals per sex per dose:
10 male rats, 10 female rats , 20 female rats at dose 2000mg/kg
Control animals:
no

Results and discussion

Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LD50
Effect level:
1 390 mg/kg bw
Sex:
female
Dose descriptor:
LD50
Effect level:
ca. 1 250 mg/kg bw

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information harmful if swallowed Criteria used for interpretation of results: EU