Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 225-924-3 | CAS number: 5153-24-2
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
In the non-GLP Ames test with zirconium di(acetate) oxide, performed according to a protocol similar to OECD guideline 471, the substance was tested in Salmonella typhimurium strains TA98, TA100, TA1535 and TA1537 using the plate incorporation and preincubation method (BASF AG, 1986). The tests were performed in triplicate, with and without metabolic activation, at test concentrations 0, 20, 100, 500, 2500 and 5000 μg/plate. The substance did not induce an increase in the number of revertants in any test, at any concentrations, with and without metabolic activation. No cytotoxicity was observed. Based on the results, the substance is considered to be negative in the Ames test.
Short description of key information:
In a non-GLP comparable to guideline Ames test, zirconium di(acetate) oxide did not induce an increase in the number of revertants in Salmonella typhimurium strains TA98, TA100, TA1535 and TA1537 with and without metabolic activation.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Based on the negative results in the Ames test, classification of zirconium di(acetate) oxide for genotoxicity is not warranted according to EU Directive 67/548 and EU Classification, Labeling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
