Registration Dossier

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Due to insufficient documentation the study is considered not to be reliable.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1977
Report date:
1991

Materials and methods

Principles of method if other than guideline:
Acute dermal toxicity.
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Reference substance name:
Benzaldehyde, 2-chloro
IUPAC Name:
Benzaldehyde, 2-chloro
Constituent 2
Chemical structure
Reference substance name:
2-chlorobenzaldehyde
EC Number:
201-956-3
EC Name:
2-chlorobenzaldehyde
Cas Number:
89-98-5
Molecular formula:
C7H5ClO
IUPAC Name:
2-chlorobenzaldehyde
Details on test material:
- Name of test material (as cited in study report): o-chlorobenzaldehyde (E-757)

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
other: impervious cuff
Vehicle:
not specified
Duration of exposure:
no data
Doses:
5.0 - 20.0 g/kg
No. of animals per sex per dose:
3 animals at all
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
approximate LD50
Effect level:
ca. 20 000 mg/kg bw

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Regarding the results of the study, the LD50 after dermal exposure of guinea pigs is ca. 20000 mg/kg bw. The study has been judged not to be reliable due to insufficient documentation.