Registration Dossier
Registration Dossier
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EC number: 223-622-6 | CAS number: 3982-91-0
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
There is no study available which investigates the possible skin sensitizing property of thiophosphoryl trichloride. However, according to ANNEX VII 8.3 Column 2 specific rules for adaption from column 1 of Regulation (EC) No. 1907/2006 (REACH) such a study does not need to be conducted, because the available information indicates that thiophosphoryl trichloride should be classified for corrosivity. For example has a 10% aqueous solution of thiophosphoryl trichloride a pH of 1.7.
The hydrolysis of a 30% aqueous thiophosphoryl chloride solution in CD3CN was evaluated by NMR spectroscopy. After 2.5 h as main components S=P(OH)2Cl and S=P(OH)3 and minor amounts of O=P(OH)2Cl and H3PO4 were found.
After 9 hours as main component S=P(OH)3 and minor amounts of O=P(OH)2Cl and H3PO4 were detected.
Due to analytical limitations of the method used, hydrogen chloride can not be detected, but the formation of HCl is predicted based on the stoichiometry of the hydrolysis reaction.
Phosphoric acid and hydrogen chloride are not classified as skin sensitisers according Regulation (EC) No 1272/2008 Annex VI Table 3.2.
Migrated from Short description of key information:
There is no study available which investigate the possible skin sensitizing property of thiophosphoryl chloride.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
No skin sensitisation study is availble for thiophosphoryl chloride and not necessary due to the corrosive properties of the substance (see discussion). A classification for the hydrolysis products is not appropriate, because no protein binding potency of the hydrolysis products is expected.
Therefore for thiophosphoryl chloride a classification as skin sensitiser is not justifed.
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