Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1988
Report date:
1988

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
2,4,6-tri-sec-butylphenol
EC Number:
227-572-6
EC Name:
2,4,6-tri-sec-butylphenol
Cas Number:
5892-47-7
Molecular formula:
C18H30O
IUPAC Name:
2,4,6-tris(butan-2-yl)phenol
Test material form:
liquid
Details on test material:
Product-Nr. /Code: GTGD 155

Test animals

Species:
rat
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: sesame oil
Doses:
2000 mg/kg bw
No. of animals per sex per dose:
5
Control animals:
no

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
discriminating dose
Effect level:
2 000 mg/kg bw
Based on:
test mat.
Remarks on result:
not determinable due to absence of adverse toxic effects
Mortality:
no mortality found.
Clinical signs:
unspecific clinical signs such as piloerection,salivation and hunched postur immediately after treatment and persisted up to the observation day 2.
Body weight:
Normal body weight development recorded.
Gross pathology:
No gross pathology performed.

Any other information on results incl. tables

Each 5 male and female rats were treated with test material at dose of 2000 mg/kg bw.

Unspecific clinical signs such as piloerection,salivation and hunched posture were observed starting immediately after the treatement at dose of 2000 mg/kg bw and persisted up to observation day of 2. No effect was found onwards. The LD50 is determined to be higher than 2000 mg/kg bw for rats.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The registration substance was investigated for its acute oral toxicity according to OECD 401. The LD50 was found to be higher than 2000 mg/kg bw.
Executive summary:

The registration substance was investigated for its acute oral toxicity according to OECD 401. Unspecific toxicity occured such as piloerection, salivation and hunched posture starting immediately after treatment at dose of 2000 mg/kg bw. By the observation day 3 the treated animals seemed to be fully recovered. The LD50 is determined to be higher than 2000 mg/kg bw.

Categories Display