2,4,6-tri-sec-butylphenol

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1988

Report date:

1988

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

2,4,6-tri-sec-butylphenol

EC Number:

227-572-6

EC Name:

2,4,6-tri-sec-butylphenol

Cas Number:

5892-47-7

Molecular formula:

C18H30O

IUPAC Name:

2,4,6-tris(butan-2-yl)phenol

Test material form:

liquid

Details on test material:

Product-Nr. /Code: GTGD 155

Test animals

Species:

rat

Sex:

male/female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

other: sesame oil

Doses:

2000 mg/kg bw

No. of animals per sex per dose:

5

Control animals:

no

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

discriminating dose

Effect level:

2 000 mg/kg bw

Based on:

test mat.

Remarks on result:

not determinable due to absence of adverse toxic effects

Mortality:

no mortality found.

Clinical signs:

unspecific clinical signs such as piloerection,salivation and hunched postur immediately after treatment and persisted up to the observation day 2.

Body weight:

Normal body weight development recorded.

Gross pathology:

No gross pathology performed.

Any other information on results incl. tables

Each 5 male and female rats were treated with test material at dose of 2000 mg/kg bw.

Unspecific clinical signs such as piloerection,salivation and hunched posture were observed starting immediately after the treatement at dose of 2000 mg/kg bw and persisted up to observation day of 2. No effect was found onwards. The LD50 is determined to be higher than 2000 mg/kg bw for rats.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

The registration substance was investigated for its acute oral toxicity according to OECD 401. The LD50 was found to be higher than 2000 mg/kg bw.

Executive summary:

The registration substance was investigated for its acute oral toxicity according to OECD 401. Unspecific toxicity occured such as piloerection, salivation and hunched posture starting immediately after treatment at dose of 2000 mg/kg bw. By the observation day 3 the treated animals seemed to be fully recovered. The LD50 is determined to be higher than 2000 mg/kg bw.