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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1988
Report date:
1988

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2,4,6-tri-sec-butylphenol
EC Number:
227-572-6
EC Name:
2,4,6-tri-sec-butylphenol
Cas Number:
5892-47-7
Molecular formula:
C18H30O
IUPAC Name:
2,4,6-tris(butan-2-yl)phenol
Test material form:
liquid
Details on test material:
Product-Nr. /Code: GTGD 155

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
unchanged (no vehicle)
Duration of treatment / exposure:
Single application
Observation period:
14 days
Number of animals:
3

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
animal: observations in three animals
Time point:
24/48/72 h
Score:
1.67
Max. score:
3
Reversibility:
fully reversible within: 14 days
Remarks on result:
positive indication of irritation
Irritation parameter:
edema score
Basis:
animal: observations in three animals
Time point:
24/48/72 h
Score:
0.57
Max. score:
2
Reversibility:
fully reversible within: 7 days
Remarks on result:
positive indication of irritation

Any other information on results incl. tables

Table: Skin irritation scores

Observation Time

Erythema

Oedema

Animal 1

Animal 2

Animal 3

Animal 1

Animal 2

Animal 3

1h

2

0

1

1

0

1

24h

2

2

1

0

1

1

48h

2

2

0

0

1

0

72h

3

3

0

2

0

0

7 day

4

2

-

0

0

-

14 day

0

0

-

0

0

-

Mean of 24/48/72h

2.3

2.3

0.3

0.7

0.7

0.3

Table: Observations of treated area

Observation Time

Animal 1

Animal 2

Animal 3

Discoloration

Dry/

Rough/

Chapped

Scaling/

Desquamation/

New skin

Discoloration

Dry/

Rough/

Chapped

Scaling/

Desquamation/

New skin

Discoloration

Dry/

Rough/

Chapped

Scaling/

Desquamation/

New skin

1h

 

 

 

 

 

 

 

 

 

2 day

 

 

 

 

x

 

 

 

 

3 day

 

 

 

 

x

 

 

 

 

7 day

 

x

x

x

x

x

 

 

 

14 day

 

 

x

 

x

 

 

 

 

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritant) based on GHS criteria
Conclusions:
The registration substance was investigated for its skin irritaiton property according to OECD 404. It was found to be irritating to skin.
Executive summary:

The registration substance was investigated for its skin irritaiton property according to OECD 404.

Among the three rabbits treated, two rabbits exhibited erythema of mean score of 2.3 for 24,48, and 72 hours reading and exhibited discoloration, dryness and scaling at reading time 7 and 14 day. The registration substance was found to be irritating to skin.

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