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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1988
Report date:
1988

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2,4,6-tri-sec-butylphenol
EC Number:
227-572-6
EC Name:
2,4,6-tri-sec-butylphenol
Cas Number:
5892-47-7
Molecular formula:
C18H30O
IUPAC Name:
2,4,6-tris(butan-2-yl)phenol
Test material form:
liquid
Details on test material:
Product-Nr. /Code: GTGD 155

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not required
Amount / concentration applied:
0.1mL
Duration of treatment / exposure:
single application
Observation period (in vivo):
up to 72 hours if no effect at reading time 72 hours; up to 7 days if no effect at reading time 7 day; up to 14 days if still effect present at reading time 7 day.
Number of animals or in vitro replicates:
3

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
other: 24, 48, 72 h
Score:
0
Max. score:
0
Reversibility:
fully reversible within: 48 hours
Irritation parameter:
iris score
Basis:
mean
Time point:
other: 24, 48, 72 hours
Score:
0
Max. score:
0
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
other: 24, 48, 72 hours
Score:
0.44
Max. score:
2
Reversibility:
fully reversible within: 48 hours
Remarks on result:
no indication of irritation
Irritation parameter:
chemosis score
Basis:
mean
Time point:
other: 24, 48, 72 hours
Score:
0.33
Max. score:
1
Reversibility:
fully reversible within: 48hours
Remarks on result:
no indication of irritation

Any other information on results incl. tables

Eye Irritation Score

Reading time

Animal

Opacity

Iris

Conjunctivae

Redness

Chemosis

1h

1

0

0

2

2

2

0

0

1

2

3

0

0

2

3

24 hours

1

0

0

1

1

2

0

0

2

1

3

0

0

1

1

48 hours

1

0

0

0

0

2

0

0

0

0

3

0

0

0

0

72 hours

1

0

0

0

0

2

0

0

0

0

3

0

0

0

0

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The registration substance is not irritating according to the results obtained in the OECD 405 study.
Executive summary:

The registration substance was investigated for its eye irritation property according to the OECD 405. Schwelling and redening of conjunctivae was observed only at reading time of 24 hours. No classification is warranted.

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