Registration Dossier
Registration Dossier
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EC number: 700-536-1 | CAS number: 25628-08-4
Toxicity to reproduction
Administrative data
- Endpoint:
- two-generation reproductive toxicity
- Remarks:
- based on test type (migrated information)
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: secondary literature (review)
Data source
Materials and methods
Test material
- Reference substance name:
- Potassium 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulphonate
- EC Number:
- 249-616-3
- EC Name:
- Potassium 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulphonate
- Cas Number:
- 29420-49-3
- IUPAC Name:
- potassium 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate
Constituent 1
Results and discussion
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Applicant's summary and conclusion
- Executive summary:
P generation male NOAEL:
100 mg/kg bw/day. Based on treatment-related microscopic changes in the liver and kidney at 300 mg/kg bw/day.
P generation female NOAEL:
100 mg/kg bw/day Based on treatment-related microscopic changes in the kidney at 300 mg/kg bw/day.
P generation male and female reproductive NOAEL:
1000 mg/kg bw/day No effect in reproductive parameters at 1000 mg/kg bw/day.
F1 litter (development) NOAEL1000 mg/kg bw/dayNo treatment-related effects were observed in the F1 litter at 1000 mg/kg bw/day.
F1 generation male NOAEL: 100 mg/kg bw/day Based on treatment-related microscopic changes in the liver and kidney at 300 mg/kg bw/day.
F1 generation female NOAEL: 100 mg/kg bw/day Based on treatment-related microscopic changes in the kidney at 300 mg/kg bw/day.
F1 generation male and female reproductive NOAEL 1000 mg/kg bw/day No effect in mating, fertility or maternal delivery parameters at 1000 mg/kg bw/day.
F2 litter NOAEL 1000 mg/kg bw/day No treatment-related effects were observed in the F2 generation pups at 1000 mg/kg bw/day.
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