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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1981-01-27 to 1981-02-12
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study equivalent to guideline. non-GLP

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1981
Report date:
1981

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Dihydro-3-(tripropenyl)furan-2,5-dione
EC Number:
295-556-6
EC Name:
Dihydro-3-(tripropenyl)furan-2,5-dione
Cas Number:
92077-08-2
Molecular formula:
R-C4H3O3 , whereas R=C8-C10-alkyl-(branched, unsaturated)
IUPAC Name:
3-[(1E)-2-methyloct-1-en-1-yl]oxolane-2,5-dione

Test animals

Species:
rat
Strain:
Wistar
Sex:
female
Details on test animals or test system and environmental conditions:
female wistar rats (Hoe WISKf(SPF71))
body weight: 200-222g (x = 209,2 g, s = ± 7,69 g, n = 20)

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: sesam oil
Details on oral exposure:
oral gavage of 25%-solution in sesam oil (25 glad 100 ml)
Doses:
1000 mg/kg bw, 2000 mg/kg bw
No. of animals per sex per dose:
10
Control animals:
no

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
> 1 000 - < 2 000 mg/kg bw
Mortality:
1000 mg/kg bw: 1/10
2000 mg/kg bw: 10/10
Fatally poisoned animals died within 1-5 days after application.
Clinical signs:
The following symptoms were observed: passivity, squat, long-legged position, stomach tightened. Edge-fed, hyporeflexia, narrowed eyelids and bristling hair.
Body weight:
The body weight gain of surviving animals was normal.
Gross pathology:
The section of dead animals showed macroscopically the following findings: red gastrointestinal-intestinal tract, small intestine with reddish-brown fluid filled, lung colored intense red, sometimes mottled brownish, liver spotted pale brown, adrenal gland stained dark red.

The section of the surviving test animals showed no macroscopically findings.

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category IV
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The LD50 of the substance is in the range of 1000-2000mg/kg bw.
Executive summary:

The acute oral toxicity of the substance was tested by oral gavage of 25% solution in sesam oil to 10 femal wistar rats per dose (1000 + 2000 mg/kg bw). At low dose 1/10 and at high dose 10/10 animals died within 1-5h after application.

The LD50 was determined to be in the range of 1000 -2000 mg/kg bw.