Paraffin oils

Basic toxicokinetics

Administrative data

Endpoint:

basic toxicokinetics

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Referred in a recognized source of peer reviewed scientific data on chemicals

Data source

Reference

Reference Type:

review article or handbook

Title:

Toxicological Profile for Total Petroleum Hydrocarbons (TPH)

Author:

ATSDR

Year:

1999

Bibliographic source:

ATSDR, September 1999.

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: Scientific peer review report

Principles of method if other than guideline:

Scientific peer review report

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Paraffin oils/waxes

IUPAC Name:

Paraffin oils/waxes

Results and discussion

Any other information on results incl. tables

Study results:

Aliphatic hydrocarbon C>16 (C16 –C35) fraction may be poorly absorbed via oral, inhalation or dermal exposure routes, distributed to the liver and fatty tissues, slowly metabolized to fatty acids or triglycerides, and excreted with the feces via the bile and as urine metabolites.

 

The data on toxicokinetics of Mineral Paraffin Oil suggest that long-chain aliphatic hydrocarbons have only limited absorption potential after inhalation, oral and ingestion exposure routes. Thus, animal studies show that up to 95 -99% of ingested food-grade mineral oil leaves the body unchanged with the faeces, and only up to 5% being absorbed via the intestinal mucosa. The absorbed Mineral Paraffin Oil is distributed to the liver and fatty tissues. Aliphatic hydrocarbons in this fraction are not expected to undergo extensive metabolism in animals or humans.