2-Thiopheneacetic acid, .alpha.-hydroxy-.alpha.-2-thienyl-, methyl ester

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2001

Report date:

2001

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Test type:

acute toxic class method

Test material

Test material information

Constituent 1

Reference substance name:

Di-2-thienylglycolic acid methyl ester

Cas Number:

26447-85-8

Molecular formula:

C11 H10 O3 S2

IUPAC Name:

Di-2-thienylglycolic acid methyl ester

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Doses:

200 mg/kg and 2000 mg/kg

No. of animals per sex per dose:

3 male and 3 female per dose

Control animals:

not specified

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Based on:

test mat.

Applicant's summary and conclusion

Interpretation of results:

practically nontoxic

Remarks:

Migrated information Criteria used for interpretation of results: OECD GHS

Conclusions:

Considering the reported data of this toxicity test it can be stated that the test item BA 679 Thienyl-glycolester has no acute toxic characteristics.
The LD50 was determined to be > 2000 mglkg bw.