Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
between June 2010 and July 2010
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study conducted in accordance with generally accepted scientific principles, possibly with incomplete reporting or minor methodological deficiencies, which do not affect the quality of relevant results.
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2010
Report date:
2010

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Based on the GHS Annex 9 Guidance, the assessment of partition coefficient within this report will be conducted utilizing the KOWWIN™ programme offered by the US Environmental Protection Agency.
GLP compliance:
no
Type of method:
other: QSAR
Partition coefficient type:
other: QSAR

Test material

Constituent 1
Reference substance name:
Pellicer
IUPAC Name:
Pellicer

Study design

Analytical method:
other: not applicable

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
-0.37 - 3.51
Remarks on result:
other: please see attached document for further information
Details on results:
Molecular weight ranges between 791.02 and 834.99.

Any other information on results incl. tables

19 of the 28 (68%) possible structures has a calculated partition coefficient value of less than 3.

Log Kow calculated values are all less than 4 for every possible component.

Each substance is of molecular weight > 700 units, the current “cut-off” limit of molecular size for which substances are anticipated to bioaccumulate. (This does not take account of the proposed revised limit of 1000 currently under consideration).

Applicant's summary and conclusion

Conclusions:
Each component therefore is NOT anticipated to be potentially bioaccumulative, and by proxy, the substance as a whole is considered to be not bioaccumulative based on the considerations of GHS (and CLP).
Executive summary:

Taking into consideration all of the above guidance and information, the following can be concluded:

1) Log Kow calculated values are all less than 4 for every possible component.

2) Each substance is of molecular weight > 700 units, the current “cut-off” limit of molecular size for which substances are anticipated to bioaccumulate. (This does not take account of the proposed revised limit of 1000 currently under consideration).

3) The above indicates that the substance does not have the potential for bioaccumulation.