Registration Dossier
Registration Dossier
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EC number: 432-130-2 | CAS number: 119345-01-6
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Not specified
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted to GLP (taken from SNIF file). Registrant referring to studies >12 years old at the permission of ECHA.
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- GLP compliance:
- yes
- Test type:
- other: Not specified
- Limit test:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 432-130-2
- EC Name:
- -
- Cas Number:
- 119345-01-6
- Molecular formula:
- Not applicable ( a generic molecular formula cannot be provided for this UVCB substance)
- IUPAC Name:
- Reaction products of phosphorous trichloride, with 1,1′-biphenyl and 2,4-bis(1,1-dimethylethyl)phenol
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- CMC (carboxymethyl cellulose)
- Remarks:
- 4%
- Details on dermal exposure:
- no data
- Duration of exposure:
- 24 h
- Doses:
- no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Details on study design:
- no data
- Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- not specified
- Mortality:
- Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0 - Clinical signs:
- Signs of toxicity related to dose levels: mortality: no mortality during the test.
Clinical signs: No clinical signs have been observed during the test. - Body weight:
- Body weight: Two female animals have lost weight in the first week of observation.
- Gross pathology:
- No effect on the bodies.
- Other findings:
- Signs of toxicity (local): stain: no staining.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- LD50 > 2000 mg/kg bw
- Executive summary:
Information from migrated NONS file, as per inquiry number06-0000020725-70-0000, permission to refer granted by ECHA.
Study conducted to GLP (taken from SNIF file). Registrant referring to studies >12 years old at the permission of ECHA.
LD50 > 2000 mg/kg bw
The substance is not classified.
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