Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

Administrative data

direct observations: clinical cases, poisoning incidents and other
Type of information:
experimental study
Adequacy of study:
other information
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Meets generally accepted scientific standards, well documented and acceptable for assessment

Data source

Reference Type:
Titanium tetrachloride burns to the eye
Chitkara DK, McNeela BJ
Bibliographic source:
British Journal of Ophthalmology 76: 380-382

Materials and methods

Study type:
poisoning incident
Endpoint addressed:
eye irritation
Principles of method if other than guideline:
Eight cases of chemicals burns of the eyes from titanium tetrachloride are presented.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Titanium tetrachloride
EC Number:
EC Name:
Titanium tetrachloride
Cas Number:
Molecular formula:
titanium tetrachloride


Type of population:
- Number of subjects exposed: 8
- Sex: all male
- Age: 20, 39, 19, 46, 42, 42, 21 years, one unknown
- Race: unknown
Ethical approval:
not applicable
Route of exposure:
Reason of exposure:
Details on exposure:
All eight patients were accidentally exposed to titanium tetrachloride splashes. The exposure occured on various parts of the body mainly face, eyes and skin

Results and discussion

Clinical signs:
The severity of the clinical signs was dependent on the exposure. Titanium tetrachloride can lead to severe chemical burns on the eyes an skin. The following observations were made on some of the workers: Hypopyon, glaucoma, entropion, trichiasis, corneal scarring and vascularisation, enucleation, cataracis, corneal perforation, corneal neovascularisation, symblepharon, pseudoterygium, pulmonary oedema.

Any other information on results incl. tables

Due to the severe eye damage observed in some of the clinical cases, titanium tetrachloride has to be classified as posing the risk of serious eye damage (R41) accoring to EU- and as eye irritant Cat. 1 according to GHS-criteria.

Applicant's summary and conclusion