Registration Dossier
Registration Dossier
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EC number: 205-483-3 | CAS number: 141-43-5
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: published in a peer reviewed journal. Results were reproduced in 3 different laboratories. no strain was included for detecting cross-linking mutagens.
Data source
Reference
- Reference Type:
- publication
- Title:
- Salmonella Mutagenicity Tests: II. Results from Testing 270 Chemicals.
- Author:
- Mortelmans K., Haworth S., Lawlor T., Speck W., Tainer B., and Zeiger E.
- Year:
- 1 986
- Bibliographic source:
- Environmental Mutagenisis Volume 8, Supplement 7:1-119
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Deviations:
- yes
- Remarks:
- 4 strains used
- GLP compliance:
- no
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 2-aminoethanol
- EC Number:
- 205-483-3
- EC Name:
- 2-aminoethanol
- Cas Number:
- 141-43-5
- Molecular formula:
- C2H7NO
- IUPAC Name:
- 2-aminoethanol
- Details on test material:
- Purity >99%
Constituent 1
Method
- Target gene:
- histidine mutation
Species / strain
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Test concentrations with justification for top dose:
- Not reported
- Vehicle / solvent:
- Not reported
Results and discussion
Test results
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- not specified
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
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