2-(phenylmethoxy)naphthalene

Genetic toxicity: in vitro

Administrative data

Endpoint:

in vitro gene mutation study in bacteria

Remarks:

Type of genotoxicity: gene mutation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: reference study data from SNIF file

Data source

Reference

Reference 1

Reference Type:

other: SNIF data provided by ECHA

Title:

Unnamed

Year:

1990

Report date:

1990

Reference 2

Reference Type:

secondary source

Title:

Unnamed

Year:

1990

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 471 (Bacterial Reverse Mutation Assay)

GLP compliance:

yes

Type of assay:

bacterial reverse mutation assay

Test material

Test material information

Constituent 1

Reference substance name:

2-(phenylmethoxy)naphthalene

EC Number:

405-490-3

EC Name:

2-(phenylmethoxy)naphthalene

Cas Number:

613-62-7

Molecular formula:

C17 H14 O

IUPAC Name:

2-(benzyloxy)naphthalene

Method

Target gene:

his-

Species / strain

Species / strain / cell type:

other: TA98, TA100, TA1535, TA1537 and TA1538

Metabolic activation:

with and without

Metabolic activation system:

rat liver S9

Test concentrations with justification for top dose:

0, 25, 74, 222, 667, 2000 µg/plate

Vehicle / solvent:

DMSO

Controls

Untreated negative controls:

not specified

Negative solvent / vehicle controls:

yes

True negative controls:

not specified

Positive controls:

yes

Positive control substance:

other: 2-aminoanthracene was used in the presence of S9 in all the strains and in the absence of S9, 2-nitrofluorene was used in strains TA98 and TA1538, sodium azide in strains TA100 and TA1535, and 2-aminoacridine in strain TA1537.

Details on test system and experimental conditions:

All dose levels were plated in triplicate

Results and discussion

Test results

Species / strain:

other: TA98, TA100, TA1535, TA1537 and TA1538

Metabolic activation:

with and without

Genotoxicity:

negative

Cytotoxicity / choice of top concentrations:

cytotoxicity

Remarks:

1000 µg/plate

Vehicle controls validity:

valid

Untreated negative controls validity:

not specified

Positive controls validity:

valid

Additional information on results:

precipitation occured from 222 µg/plate

Remarks on result:

other: all strains/cell types tested

Remarks:

Migrated from field 'Test system'.