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Toxicological information

Toxicity to reproduction

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Administrative data

Endpoint:
one-generation reproductive toxicity
Remarks:
based on test type (migrated information)
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: reference study data from SNIF file

Data source

Reference
Reference Type:
other: SNIF data provided by ECHA
Title:
Unnamed
Report date:
1990

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 415 [One-Generation Reproduction Toxicity Study (before 9 October 2017)]
GLP compliance:
yes
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-(phenylmethoxy)naphthalene
EC Number:
405-490-3
EC Name:
2-(phenylmethoxy)naphthalene
Cas Number:
613-62-7
Molecular formula:
C17 H14 O
IUPAC Name:
2-(benzyloxy)naphthalene

Test animals

Species:
rat
Strain:
other: Wistar Hanlbon (SPF)
Sex:
male/female

Administration / exposure

Route of administration:
oral: feed
Doses / concentrationsopen allclose all
Remarks:
Doses / Concentrations:
males: 0, 43.6, 224.2 and 1137.6 mg/kg bw
Basis:

Remarks:
Doses / Concentrations:
females: 0, 71.1, 351.4 and 1669.1 mg/kg bw
Basis:

No. of animals per sex per dose:
25
Control animals:
yes, plain diet

Results and discussion

Results: P0 (first parental generation)

Details on results (P0)

Increased food intake in males. In females decreased food intake and weight loss was reported prior and during pregnancy when given 351.4 mg/kg bw (relative) and 1669.1 mg/kg bw (relative and absolute).
No dose dependent change in conception rate and gestation length. A reduction of implantations and embryo losses after implantation were reported.
Litter size from test group 4 (1669.1 mg/kg bw in females) was reduced. Litter size from test group 3 (351.4 mg/kg bw in females ) was also reduced but still within the range of the historical laboratory control data.

Results: F1 generation

Details on results (F1)

A decrease in average weight was reported in litter from groups 4 (1669.1 mg/kg bw in females and 1137.6 mg/kg bw in males) and 3 (351.4 mg/kg bw in females and 224.2 mg/kg bw in males) after 21 days of lactation. No structural abnormalities compared with controls have been reported.

Effect levels (F1)

Dose descriptor:
NOAEL
Generation:
F1
Effect level:
351.4 mg/kg bw/day (nominal)
Based on:
test mat.
Sex:
male/female
Basis for effect level:
other: Litter size reduction in high dose group

Overall reproductive toxicity

Reproductive effects observed:
not specified

Applicant's summary and conclusion

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