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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Study period:
1962
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Range-Finding Toxicity Data: List VI
Author:
Smyth and Carpenter
Year:
1962
Bibliographic source:
Amer. Ind. Hyg. Ass. J., 23:95-107

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
GLP compliance:
no
Test type:
other: Range-finding study
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent

Test animals

Species:
rat
Strain:
other: albino
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
other: unchanged (no vehicle)
Details on inhalation exposure:
Rats were exposed to a saturated air concentration of DPM for a period of 8 hours.
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
8 h
Concentrations:
not specified
No. of animals per sex per dose:
6
Control animals:
no
Details on study design:
Rats were exposed by whole body inhalation to a saturated atmosphere of DPM for the maximum exposure duration of 8 hours and observed for any mortalities after 14 days.
Statistics:
not specified

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC0
Effect level:
mg/L air (nominal)
Exp. duration:
8 h
Remarks on result:
other: 14 day follow up
Mortality:
None
Clinical signs:
other: Not reported
Body weight:
Not reported
Gross pathology:
Not reported

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: OECD GHS
Conclusions:
DPM is not acutely toxic to rats by inhalation, at maximal achievable air concentrations.
Executive summary:

Six rats were exposed by whole body inhalation to air saturated with DPM vapour for a period of 8 hours, and followed for 14 days. No mortality was observed.