Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2011
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
review article or handbook
Title:
Fragrance material review on phenethyl alcohol
Author:
J.Scognamiglio, et al.
Year:
2011
Bibliographic source:
Food and chemical toxicology, doi: 10.1016/j.fct2011.10.028

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: refer to article
Deviations:
no
GLP compliance:
not specified
Test type:
fixed dose procedure

Test material

Constituent 1
Chemical structure
Reference substance name:
2-phenylethanol
EC Number:
200-456-2
EC Name:
2-phenylethanol
Cas Number:
60-12-8
Molecular formula:
C8H10O
IUPAC Name:
2-phenylethanol

Test animals

Species:
rat
Strain:
Osborne-Mendel
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
>= 1 580 - <= 2 020 mg/kg bw
Based on:
test mat.
95% CL:
>= 1.4 - <= 1.7

Applicant's summary and conclusion