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Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Link to relevant study record(s)

Description of key information

In a bioaccumulation study according to OECD TG 305 bioconcentration factors (BCF) for the test substance (as described in section 1.2) were determined in Japanese Carp incubated in a continuous flow through system. 14C-labelled test substance was dissolved with the use of dispersant with 28 days of exposure. Of the two concentrations tested, 0.5 mg/L was higher than the water solubility (< 0.1 mg/L), whereas 0.05 mg/L is considered to represent a water soluble concentration. It did not appear that the steady-state was achieved at either concentration level. Test water and test fish was analysed during the exposure period on days 7, 14, 21, 23 and 28. BCF were calculated as the ratio of the concentration of the test substance between fish and the exposure water. The BCF was 49 for the high concentration level and < 30 for the low concentration level. 
Additionally, three different QSAR calculations have been performed.
(1) CATALOGIC v5.11.2: BCF = 29.78
(2) T.E.S.T. consensus method: BCF = 225.45
(3) EPISuite v4.10: BCF = 1072 l/kg wet-wt
According to these QSAR calculations, the substance is not regarded as bioaccumulative. However, the substance was only partially (52.78 %) in the structural domain of CATALOGIC.
Further evidence of a low bioaccumulative potential is revealed by the DiamMax-average which is 1.711 nm. According to ECHA's guidance on information requirements and chemical safety assessment chapter R.11 (PBT) substances with an average maximum diameter of greater than 1.7 nm acn be considered as not B in an weight of evidence approach.
In conclusion, the substance is regarded as not bioaccumulative.

Key value for chemical safety assessment

Additional information