Registration Dossier
Registration Dossier
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EC number: 205-592-6 | CAS number: 143-22-6
Neurotoxicity
Administrative data
Description of key information
There are conclusive but not suffcient data for the classification of substance 2-(2-(2-butoxyethoxy)ethoxy)ethanol with regard to Neurotoxicity.
Key value for chemical safety assessment
Effect on neurotoxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 5 025.1 mg/kg bw/day
Effect on neurotoxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- NOAEC
- 218.5 mg/m³
Effect on neurotoxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 2 542 mg/kg bw/day
Additional information
oral exposure
The substance triethylene glycol butyl ether (TEGBE or 2 -(2 -(2 butoxyethoxy)ethoxy)ethanol, the subject of this dossier) is expected to exhibit very similar toxicity due to its close structural similarity to Triethylene glycol monomethyl ether (TGME) or 2-(2-(2-methoxyethoxy)ethoxy)ethanol. Comparable metabolism would occur.
On a molecular weight scaled basis, the NOAEL would be5025.1 mg/kg bw day.
(4000x 206.28) /164.2 =5025.1mg/kg bw/day
dermal exposure
The substance triethylene glycol butyl ether (TEGBE or 2 -(2 -(2 butoxyethoxy)ethoxy)ethanol, the subject of this dossier) is expected to exhibit very similar toxicity due to its close structural similarity to 2-(2-butoxyethoxy)ethanol. Comparable metabolism would occur.
On a molecular weight scaled basis, the NOAELwould be2542mg/kg bw day.
(2000x 206.28) /162.3 =2542mg/kg bw/day
Inhalation exposure:
The oral dose for the rat is converted to the corresponding air concentration using a standard breathing volume for the rat (1.15 m3/kg for 24 hours exposure. The resulting air concentration needs to be additionally corrected for 24 hlight activity (20 m3), assuming 100 % absorption for both routes.
NOAEL rat 5025.1mg/kg bw/day
÷1.15 m3/kgbw
÷20m3/rat
NOAECrat = 218. 5 mg/m3
Justification for classification or non-classification
There are conclusive but not suffcient data for the classification of substance 2-(2-(2-butoxyethoxy)ethoxy)ethanol with regard to neurotoxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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