Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: other routes

Currently viewing:

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Abstract only, full article in chinese

Data source

Reference
Reference Type:
other: Publication Abstract
Title:
Acute toxicity and target organs assessment of subchronic exposure to hydroxylammonium nitrate in wistar rats
Author:
An H., Liu S-X, Gao L-H, Yang H., Cao J.
Year:
2007
Bibliographic source:
Journal of Toxicology

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Rats were administered hydroxylammonium nitrate by intraperitoneal injection and observed for 14 days.
GLP compliance:
not specified
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Hydroxylammonium nitrate
EC Number:
236-691-2
EC Name:
Hydroxylammonium nitrate
Cas Number:
13465-08-2
Molecular formula:
H3NO.HNO3
IUPAC Name:
hydroxylammonium nitrate

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
not specified
Details on exposure:
Rats were administered a range of doses of hydroxylammonium nitrate once by intraperitoneal injection.
Doses:
Specific range of doses not stated.
No. of animals per sex per dose:
Not data.
Control animals:
not specified
Details on study design:
Animals were injected with a single dose of hydroxyalmmonium hydrochloride and observed for up to 14 days.
Statistics:
Not data.

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 139.3 mg/kg bw
Based on:
not specified
95% CL:
ca. 132.3 - 146.7
Mortality:
Toxic signs (no further details stated) and morbity were observed within 14 days.
Clinical signs:
Not data.
Body weight:
No data.
Gross pathology:
No data.
Other findings:
No data.

Applicant's summary and conclusion

Executive summary:

Rats were administered hydroxylammonium nitrate via intraperitoneal injection and observed for 14 days for toxic signs and morbity. The LD50 was 139.3 mg/kg (lower 95% confidence level 132.3 mg/kg, upper 95% confidence level 146.7 mg/kg). This study did not follow standardised guidelines and only the abstract was available, the reliability of the study is therefore considered not assignable.