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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Abstract only, full article in chinese

Data source

Reference
Reference Type:
other: Publication Abstract
Title:
Acute toxicity and target organs assessment of subchronic exposure to hydroxylammonium nitrate in wistar rats
Author:
An H., Liu S-X, Gao L-H, Yang H., Cao J.
Year:
2007
Bibliographic source:
Journal of Toxicology

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Rats were administered hydroxylammonium nitrate by intraperitoneal injection and observed for 14 days.
GLP compliance:
not specified
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Hydroxylammonium nitrate
EC Number:
236-691-2
EC Name:
Hydroxylammonium nitrate
Cas Number:
13465-08-2
Molecular formula:
H3NO.HNO3
IUPAC Name:
hydroxyazanium nitrate

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
not specified
Details on exposure:
Rats were administered a range of doses of hydroxylammonium nitrate once by intraperitoneal injection.
Doses:
Specific range of doses not stated.
No. of animals per sex per dose:
Not data.
Control animals:
not specified
Details on study design:
Animals were injected with a single dose of hydroxyalmmonium hydrochloride and observed for up to 14 days.
Statistics:
Not data.

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 139.3 mg/kg bw
Based on:
not specified
95% CL:
ca. 132.3 - 146.7
Mortality:
Toxic signs (no further details stated) and morbity were observed within 14 days.
Clinical signs:
Not data.
Body weight:
No data.
Gross pathology:
No data.
Other findings:
No data.

Applicant's summary and conclusion

Executive summary:

Rats were administered hydroxylammonium nitrate via intraperitoneal injection and observed for 14 days for toxic signs and morbity. The LD50 was 139.3 mg/kg (lower 95% confidence level 132.3 mg/kg, upper 95% confidence level 146.7 mg/kg). This study did not follow standardised guidelines and only the abstract was available, the reliability of the study is therefore considered not assignable.