Registration Dossier
Registration Dossier
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EC number: 203-402-6 | CAS number: 106-48-9
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given.
Data source
Reference
- Reference Type:
- other: ECHA disseminated dossier
- Title:
- Unnamed
- Report date:
- 1981
Materials and methods
- Principles of method if other than guideline:
- 1 male and 1 female rabbit were tested for eye irritation/corrosion by application of test substance into the conjuctival sac.
- GLP compliance:
- no
- Remarks:
- prior to GLP
Test material
- Reference substance name:
- 4-chlorophenol
- EC Number:
- 203-402-6
- EC Name:
- 4-chlorophenol
- Cas Number:
- 106-48-9
- Molecular formula:
- C6H5ClO
- IUPAC Name:
- 4-chlorophenol
Constituent 1
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: over all time points up to 6 days
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- not reversible
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: mean over all time points up to 6 days
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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