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EC number: 201-178-4 | CAS number: 79-11-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary source only
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Chloroacetic acid, CAS No: 79-11-8
- Author:
- OECD SIDS
- Year:
- 1 996
- Bibliographic source:
- http://www.inc hem.org/doc uments/sids/s ids/79118.pdf
- Reference Type:
- publication
- Title:
- Fundamental and Applied Toxicology, 9, 469-479
- Author:
- Berardi, M.R. et al.,
- Year:
- 1 987
- Bibliographic source:
- Monochloroacetic acid toxicity in the mouse associated with blood-brain barrier damage.
Materials and methods
- Principles of method if other than guideline:
- Mice were exposed to test concentrations up to 800 mg chloracetic acid/kg bw by the oral route to evaluate the LD50.
- GLP compliance:
- no
Test material
- Reference substance name:
- Chloroacetic acid
- EC Number:
- 201-178-4
- EC Name:
- Chloroacetic acid
- Cas Number:
- 79-11-8
- Molecular formula:
- C2H3ClO2
- IUPAC Name:
- chloroacetic acid
- Details on test material:
- - Name of test material (as cited in study report): Chloracetic acid
- Analytical purity: 99%
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- Swiss Webster
- Sex:
- male
Administration / exposure
- Route of administration:
- other: oral (no further information)
- Doses:
- up to 800 mg/kg bw
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 260 mg/kg bw
- Based on:
- test mat.
- Other findings:
- Some surviving mice exposed to concentrations around the LD50 developed front paw paralysis and brain damage. Single doses of 80, 118 or 174 mg/kg bw produced "little or no mortality".
Applicant's summary and conclusion
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