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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Secondary source only

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
Chloroacetic acid, CAS No: 79-11-8
Author:
OECD SIDS
Year:
1996
Bibliographic source:
http://www.inc hem.org/doc uments/sids/s ids/79118.pdf
Reference Type:
publication
Title:
Toxicity and pharmacokinetics of monochloracetic acid
Author:
Berardi, M. & Snyder, R.
Year:
1983
Bibliographic source:
Pharmacologist, 25, 228

Materials and methods

Principles of method if other than guideline:
Rats were exposed to the test substance by the dermal route to evaluate acute dermal toxicity.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Chloroacetic acid
EC Number:
201-178-4
EC Name:
Chloroacetic acid
Cas Number:
79-11-8
Molecular formula:
C2H3ClO2
IUPAC Name:
chloroacetic acid
Details on test material:
- Name of test material (as cited in study report): Chloracetic acid
- Analytical purity: no data

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Doses:
200 mg/kg bw

Results and discussion

Mortality:
Topical application of 200 mg/kg bw caused death (no further information given).

Applicant's summary and conclusion