Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 692-842-6 | CAS number: 1312296-85-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
The test substance was assessed for its skin sensitising potential using the Local Lymph Node Assay (LLNA) in CBA/CaOlaHsd mice (BASF SE, 2012). The study was performed according to OECD guideline 429 in compliance with GLP. Test item solution at 10, 25, and 50% (w/w) was prepared in the vehicle dimethylformamide. The highest concentration tested was the highest concentration that could be technically used.
The animals did not show any signs of systemic toxicity or local skin irritation during the course of the study and no cases of mortality were observed. A statistically significant or biologically relevant increase in ear weights was not observed in any treated group in comparison to the vehicle control group. Furthermore, the cutoff-value for a positive response regarding the ear weight index of 1.1 reported for BALB/c mice was not exceeded in any dose group
Stimulation Indices (S.I.) of 1.36, 1.42, and 1.10 were determined with the test item at concentrations of 10, 25, and 50% (w/w) in dimethylformamide, respectively. A statistically significant or biologically relevant increase in DPM value, lymph node weight and cell count was not observed in any treated group in comparison to the vehicle control group. Furthermore, the cutoff-value for a positive response regarding the lymph node cell count index of 1.55 reported for BALB/c mice was not exceeded in any dose group.
Conclusion: The test item was not a skin sensitiser under the test conditions of this study.
Migrated from Short description of key information:
Skin sensitisation (LLNA): not sensitising (BASF SE, 2012).
Respiratory sensitisation
Endpoint conclusion
- Additional information:
- Migrated from Short description of key information:
There are no data available concerning respiratory sensitisation.
Justification for classification or non-classification
Dangerous Substance Directive (67/548/EEC):
The available experimental test data for skin sensitisation are reliable and suitable for the purpose of classification under Directive 67/548/EEC. No classification is warranted concerning skin sensitisation (data conclusive but not sufficient for classification). There are no data available concerning respiratory sensitisation (no classification due to lacking data).
Classification, Labeling, and Packaging Regulation (EC) No. 1272/2008:
The available experimental test data for skin sensitisation are reliable and suitable for the purpose of classification under Regulation (EC) No. 1272/2008. No classification is warranted concerning skin sensitisation (data conclusive but not sufficient for classification).
There are no data available concerning respiratory sensitisation (no classification due to lacking data).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
