Registration Dossier
Registration Dossier
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EC number: 692-514-2 | CAS number: 133047-57-1
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 3,10-bis[(2-aminopropyl)amino]-6,13-dichloro-5,12-dioxa-7,14-diazapentacene-4,11-disulfonic acid
- EC Number:
- 692-514-2
- Cas Number:
- 133047-57-1
- Molecular formula:
- C24H24Cl2N6O8S2
- IUPAC Name:
- 3,10-bis[(2-aminopropyl)amino]-6,13-dichloro-5,12-dioxa-7,14-diazapentacene-4,11-disulfonic acid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Number of animals:
- 1 male and 2 females
- Details on study design:
- The primary skin irritation potential of the test article was investigated by topical application
of 0.5 g to 6 cm2 intact dorsal skin of each of three young adult New Zealand rabbits. The
scoring of skin reactions was performed 1, 24, 48 and 72 hours after removal of the dressing.
The scores of each animal at the following reading times (24, 48, 72 hours) were used in
calculating the respective mean values for each type of lesion.
Results and discussion
Any other information on results incl. tables
RESULTS
VIABILITY/MORTALITY AND CLINICAL SIGNS
No clinical signs of systemic toxicity were observed in the animals during the test and
observation period, and no mortality occurred.
IRRITATION
Application of the test article to healthy intact rabbit skin resulted in a primary irritation score
of 0.00.
Local signs (mean values from 24 to 72 hours) consisted of grade 0.00 erythema and grade
0.00 edema.
COLORATION
Light violet or violet staining by the test article of the treated skin was observed.
CORROSION
No irreversible alterations of the treated skin were observed nor were corrosive effects
evident on the skin.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- not irritating
- Executive summary:
not irritating
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