Registration Dossier
Registration Dossier
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EC number: 205-617-0 | CAS number: 144-15-0
Endpoint summary
Administrative data
Description of key information
Additional information
The aquatic bioaccumulation of tris(2-ethylhexyl) 2-(acetyloxy) propane-1,2,3-tricarboxylate was predicted by means of the computer program BCFBAF v3.01 (by US-EPA) using two different models. The regression-based estimate (traditional method) resulted in a bioconcentration factor (BCF) of 120 L/kg wet-wt and the Arnot-Gobas method (based on mechanistic first principles) resulted in a low BCF of 0.90 L/kg wet-wt (upper trophic), whereby the substance specific LogPow (9.96; estimated with EPIWIN) is taken into account. Based on these calculated results, a low potential for bioconcentration is to be expected (< 500 L/kg).Further, some more factors have been taken into account: In general, absorption of a chemical is possible, if the substance crosses biological membranes. This process requires a substance to be soluble, both in lipid and in water and is also dependent on its molecular weight (substances with molecular weights below 500 are favourable for absorption). In conclusion tris(2-ethylhexyl) 2-(acetyloxy)propane-1,2,3-tricarboxylate is expected to be poorly absorbed, considering its molecular weight and water solubility.
Terrestrial bioaccumulation of the substance is not a relevant endpoint of a registration under REACH at a tonnage band > 1000 tonnes.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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