Registration Dossier
Registration Dossier
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EC number: 213-243-4 | CAS number: 931-87-3
Endpoint summary
Administrative data
Description of key information
In a 28-day oral gavage study reduced body weights were noted in high dose male rats at 500 mg/kg bw/d which proved to be reversible upon 14-day recovery. The NOAEL was 150 mg/kg bw/d.
In a read across approach subchronic 6-month inhalation studies with rats, guinea pigs and rabbits were considered. A NOAEC of 300 ppm (13.4 mmol/m³) was identified based on reduced body weight at 600 ppm (26.7 mmol/m³) in male rats.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 150 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEC
- 1 500 mg/m³
- Study duration:
- subchronic
- Species:
- rat
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 150 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
Additional information
NOAEL (oral, rat) : subacute 28 -day gavage study in rats based on reduced body weight at 500 mg/kg bw/d
NOAEL (dermal, rat) calculated from 28 -day oral study, assuming a worst case of 100% dermal absorption
NOAEC (inhalation, rat) calculated from read across to 6-month repeated dose inhalation study with cyclohexene (NOAEC 300 ppm =13.4 mmol/m³) based on reduced body weight gain at 600 ppm
Justification for classification or non-classification
Based on the results in experimental studies upon repeated dosing, no classification according to EU and GHS criteria is required.
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