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Registration Dossier
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EC number: 905-276-4 | CAS number: -
Toxicity to reproduction: other studies
Administrative data
- Endpoint:
- toxicity to reproduction: other studies
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: guideline study; not available for review
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Reproductive endpoints in general toxicity studies: are they predictive?
- Author:
- Chapin RE et al.
- Year:
- 1 998
- Bibliographic source:
- Reproductive Toxicology 12, 489-494
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 990
Materials and methods
- Principles of method if other than guideline:
- Type: other: subchronic
Method: other: determination of sperm motility and concentration in males and length of oestrus cycle and vaginal cytology following repeated dose according EPA OPP 82-1 - GLP compliance:
- yes
- Type of method:
- in vivo
Test material
- Reference substance name:
- o-cresol
- EC Number:
- 202-423-8
- EC Name:
- o-cresol
- Cas Number:
- 95-48-7
- IUPAC Name:
- o-cresol
- Details on test material:
- IUCLID4 Test substance: other TS: o-cresol purity > 99 %
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- B6C3F1
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: feed
- Duration of treatment / exposure:
- 90 d
- Frequency of treatment:
- daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 1250, 5000 ppm
Basis:
- Control animals:
- yes, concurrent no treatment
- Details on study design:
- Duration of test: 90
Results and discussion
Any other information on results incl. tables
RS-Freetext:
Male:
Reproductive organ weights (R. testicle and R. epididymidis) showed no difference to the respective controls; epididymal tail weight was significantly reduced when compared to the respective control.
Spermatogonial measurements revealed no findings.
Female:
Mean estrous cycle length was significantly prolonged at 20000 ppm.
Applicant's summary and conclusion
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