Registration Dossier
Registration Dossier
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EC number: 415-030-3 | CAS number: 120298-38-6 TRUSOPT INTERMEDIATE, L-686,771
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 994
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- GLP compliance:
- yes
Test material
- Reference substance name:
- (S,S)-trans-4-(acetylamino)-5,6-dihydro-6-methyl-7,7-dioxo-4H-thieno[2,3-b]thiopyran-2-sulfonamide
- EC Number:
- 415-030-3
- EC Name:
- (S,S)-trans-4-(acetylamino)-5,6-dihydro-6-methyl-7,7-dioxo-4H-thieno[2,3-b]thiopyran-2-sulfonamide
- Cas Number:
- 120298-38-6
- Molecular formula:
- C10 H14 N2 O5 S3
- IUPAC Name:
- N-{2-methyl-1,1-dioxo-6-sulfamoyl-2H,3H,4H-1λ⁶-thieno[2,3-b]thiopyran-4-yl}acetamide
Constituent 1
Test solutions
- Vehicle:
- yes
- Details on test solutions:
- The substance was dissolved in sterile nutrient medium with the aid of a magnetic stirrer overnight to give an initial stoch solution of 100 mg/l.
Test organisms
- Test organisms (species):
- Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)
Study design
- Limit test:
- no
- Total exposure duration:
- 72 h
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 0.59 mg/L
- Basis for effect:
- biomass
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 4.1 mg/L
- Basis for effect:
- growth rate
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.21 mg/L
- Basis for effect:
- growth rate
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.21 mg/L
- Basis for effect:
- biomass
Any other information on results incl. tables
A statistically significant effect on growth (p<0.01) was observed at test concentration of 0.44 mg/l and above.
Growth (biomass) was also reduced by 15% compared with controls at 0.21 mg/l but this result was not statistically significant.
Results are based on mean measured conc. at 0 -72 h. Values ranged from 91 -104% of nominal at 0 h and 80 -130% of nominal at 72h.
Applicant's summary and conclusion
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