Registration Dossier
Registration Dossier
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EC number: 411-200-6 | CAS number: 14657-64-8 FYROL 3-HPP; HIRETAR-205; PHOSGARD PF 100
Eye irritation
Administrative data
- Endpoint:
- eye irritation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- other: ECHA inquiry result
- Title:
- Unnamed
- Year:
- 1 999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: EPA method, cfr OECD Guidelne 405, 1987
- GLP compliance:
- yes
Test material
- Reference substance name:
- 3-(hydroxyphenylphosphinyl)propanoic acid
- EC Number:
- 411-200-6
- EC Name:
- 3-(hydroxyphenylphosphinyl)propanoic acid
- Cas Number:
- 14657-64-8
- Molecular formula:
- C9H11O4P
- IUPAC Name:
- 3-[hydroxy(phenyl)phosphoryl]propanoic acid
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Test animals / tissue source
- Species:
- other: New Zealand white rabbits
Test system
- Amount / concentration applied:
- 62 MG
- Number of animals or in vitro replicates:
- 6
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Score:
- 2.4
- Max. score:
- 3
- Remarks on result:
- other: Max duration: 21h; Max. value at end of observation period: 2
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Score:
- 1.9
- Max. score:
- 2
- Remarks on result:
- other: Max duration: 21h; Max. value at end of observation period: 2
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Score:
- 2.1
- Max. score:
- 3
- Remarks on result:
- other: Max duration: 21h; Max. value at end of observation period: 4
- Irritation parameter:
- iris score
- Basis:
- mean
- Score:
- 1
- Max. score:
- 1
- Remarks on result:
- other: Max duration: 21h; Max. value at end of observation period: 1
- Irritant / corrosive response data:
- Reversibility of any observed effect: Change not fully reversible within 21 days
- Other effects:
- Additional ocular findings includedsloughing of the corneal epithelium, coreneal neovascularization and raised area on the corneal surface.
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information
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