Registration Dossier
Registration Dossier
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EC number: 411-200-6 | CAS number: 14657-64-8 FYROL 3-HPP; HIRETAR-205; PHOSGARD PF 100
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro cytogenicity / chromosome aberration study in mammalian cells
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- other: ECHA inquiry result
- Title:
- Unnamed
- Year:
- 1 999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 473 (In Vitro Mammalian Chromosome Aberration Test)
- GLP compliance:
- yes
- Type of assay:
- in vitro mammalian chromosome aberration test
Test material
- Reference substance name:
- 3-(hydroxyphenylphosphinyl)propanoic acid
- EC Number:
- 411-200-6
- EC Name:
- 3-(hydroxyphenylphosphinyl)propanoic acid
- Cas Number:
- 14657-64-8
- Molecular formula:
- C9H11O4P
- IUPAC Name:
- 3-[hydroxy(phenyl)phosphoryl]propanoic acid
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- mammalian cell line, other: Chinese hamster ovary cells
- Metabolic activation system:
- Arolor-induced rat liver S9
- Test concentrations with justification for top dose:
- Concentration range in the main test (with metabolic activation): 313 ... 5000 μg/ml
Concentration range in the main test (without metabolic activation): 313 ... 5000 μg/ml - Vehicle / solvent:
- Dimethyl sulfoxide, the test substance is soluble at 500mg
- Details on test system and experimental conditions:
- Exposure period (with metabolic activation): 4 hours
Exposure period (without metabolic activation): 4 hours
Fixation time:20 hours
Results and discussion
Test resultsopen allclose all
- Species / strain:
- other: as specified above
- Metabolic activation:
- with
- Genotoxicity:
- not specified
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- >5000 ug/ml
- Species / strain:
- other: as specified above
- Metabolic activation:
- without
- Genotoxicity:
- not specified
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- >5000 ug/ml
- Additional information on results:
- Observations:
No toxicity was observed in CHO cells when heated for 4
hours in the absence or presence of S9-action regardless of
dose level.The percentage of cells with structural and
numerical aberrations in the test article-treated group was
not significantly increased above that of the solvent
control.
The positive and solvent controls fulfilled the requirements
for a valid test.
The positive controls, cyclophosphamide and mytomycin C,
induced a significant increase in the frequency of
aberrations. Negative control values were within the normal
range - Remarks on result:
- other: other: preliminary test
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative without metabolic activation
negative with metabolic activation
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