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EC number: 608-209-4 | CAS number: 284461-73-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicity to soil microorganisms
Administrative data
- Endpoint:
- toxicity to soil microorganisms
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Dec 2009- Jan 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted with Sorafenib Tosylate according to OECD guideline under GLP
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 216 (Soil Microorganisms: Nitrogen Transformation Test)
- Deviations:
- no
- Principles of method if other than guideline:
- Not relevant
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 475207-59-1
- Cas Number:
- 475207-59-1
- IUPAC Name:
- 475207-59-1
- Details on test material:
- - Name of test material (as cited in study report): Sorafenib Tosylate BAY 54-9085
- Analytical purity: 99.5%
- Lot/batch No.: BXA4DZ4
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test substrate
- Vehicle:
- no
Test organisms
- Test organisms (inoculum):
- soil
Study design
- Total exposure duration:
- 28 d
Test conditions
- Moisture:
- 22.6%
Results and discussion
Any other information on results incl. tables
Since the inhibition value is negative, no inhibitory effect of the test item on soil microflora concerning nitrate production on day 28 was found when compared to the control soil.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The test substance shows no inhibitory effect on the nitrification of soil microflora. Owing the outcome of the test, no calculation of ECx values is
possible. The NOEC is 250 mg a.i./kg. - Executive summary:
The purpose of the study is the determination of effects on soil microflora activity of BAY 54 -9085. On day 0, all test samples (with and without lucerne meal) showed almost equal nitrate concentrations, ranging from 139.4 to 152.0 mg NO3-/kg dry soil for the samples with lucerne meal, and ranging from 162.3 to 188.1 mg NO3-/kg dry soil for the nitrification control (NC) samples (without lucerne meal). In the NC control samples (no test item, without lucerne meal), the nitrate concentration increased from an average of 172.7 mg NO3-/kg dry soil on day 0 to an average of 236.6 mg NO3-/kg dry soil on day 28. For the NC 250 samples (250 mg a.i./kg dry soil, without lucerne meal), the mean nitrate concentration increased from 167.0 mg/kg dry soil on day 0 to 294.6 mg/kg dry soil on day 28. After 28 days, the mean nitrate transformation rates in the NC samples were 2.3 and 4.6 mg NO3-/kg dry soil per day for the NC control and the NC 250 treatment, respectively. The % inhibition of the nitrification in the NC 250 treatment compared to the NC control was -99.9%. An apparent contribution (63.8 mg NO3-/kg dry soil) of the nitrogen from the test item in the nitrate formation was calculated in the NC samples without lucerne meal. The nitrate concentration in the control samples with lucerne meal increased from an average of 150.3 mg NO3-/kg dry soil on day 0 to an average of 360.7 mg NO3-/kg dry soil on day 28. For the 250 mg a.i./kg dry soil treatment with lucerne meal, the mean nitrate concentration increased from 140.6 mg/kg dry soil on day 0 to 424.4 mg/kg dry soil on day 28. After 28 days, the mean nitrate transformation rate in the control samples was 7.5 mg NO3-/kg dry soil per day. The mean nitrification rate for the 250 mg a.i./kg dry soil treatment, adjusted for the contribution of the test item, was 7.9 mg NO3-/kg dry soil per day, equivalent to an inhibition of the nitrification compared to the control of -4.6%. Since the inhibition value is negative, no inhibitory effect of the test item on soil microflora concerning nitrate production on day 28 was found when compared to the control soil.
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