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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2010-02-12
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Guideline study without GLP
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
GLP compliance:
no
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
7.1
Temp.:
22 °C
pH:
> 6 - < 7
Details on results:
see below
Measurement:
Concentration of sample solution [mg/ml]: 6.03
components (averages of 2 runs) 1 2 3
peak area [%] 3.26 28.64 68.10
retention time 5.935 7.252 8.755
capacity factor k 3.531 4.536 5.683
log k 0.55 0.66 0.75
log Pow 6.4 6.9 7.2
log Pow (average) 7.1
components (2nd chromatographic run) 1 2 3
peak area [%] 3.77 28.79 67.44
retention time 5.938 7.242 8.742
capacity factor k 3.533 4.528 5.673
log k 0.55 0.66 0.75
log Pow 6.4 6.9 7.2
log Pow (average) 7.1
log Pow 7.1
Conclusions:
log Pow of Cyclohexanol, 4-C11-12-alkyl, branched = 7.1
Executive summary:

The log Pow of Cyclohexanol, 4-C11-12-alkyl, branched was determined to be 7.1 according to OECD Guideline 117.

Description of key information

Log Kow (Pow) for Cyclohexanol, 4-C11-12-alkyl, branched measured according to OECD guideline 117 was 7.1 at approx. 22° C and a pH of 6-7.

Key value for chemical safety assessment

Log Kow (Log Pow):
7.1
at the temperature of:
22 °C

Additional information